Figure 4.

EZH2 inhibition suppressed LUAD cell proliferation and invasion. A, Cell viability in si‐EZH2 group was lower than that in NC group detected by MTT assay. And the phenomenon of reduced cell viability caused by EZH2 inhibition was restored via miR‐144‐3p inhibitor. B, Colony numbers in si‐EZH2 group were less than that in NC group detected by colony formation assay. miR‐144‐3p inhibitor could restored the colony numbers. C, Effect of si‐EZH2 on cell invasion of NCI‐H1975 and SPC‐A1 cells was detected by transwell assay, while this phenomenon was restored by cotransfecting miR‐144‐3p inhibitor and EZH2 inhibition. **P < 0.01, compared with NC group. Scale bar: 50 μm