6.

一线靶向治疗后获得性耐药T790M阳性和阴性患者临床相关因素差异

Differences in clinical relevant factors between patients with acquired drug resistance T790M positive and T790M negative after EGFR-TKI as first line therapy

Item	T790M (n=27)	T790M wild type (n=21)	P
Age (yr)			0.575
≤65	20	14
> 65	7	7
Gender			0.129
Male	4	7
Female	23	14
PS			0.381
0-1	22	19
≥2	5	2
Smoking status			0.573
Former smoker	7	4
Never smoker	20	17
Stage			0.251
Ⅱa-Ⅲa	0	1
Ⅲb-Ⅳ	27	20