Table 3.
Factors affecting disease free survival
|
Univariate analysis |
Multivariate analysis |
||||||||||||
| HR | 95%CI | P | HR | 95%CI | P | ||||||||
| Age (yr) | < 65 | 1 | 1 | ||||||||||
| ≥ 65 | 1.779 | 1.268 | 2.496 | 0.001 | 1.88 | 1.305 | 2.708 | 0.001 | |||||
| Gender | Male | 1 | |||||||||||
| Female | 0.96 | 0.686 | 1.343 | 0.812 | |||||||||
| Family history | No | 1 | |||||||||||
| Yes | 1.195 | 0.489 | 2.919 | 0.696 | |||||||||
| Smoking status | No | 1 | |||||||||||
| Yes | 0.908 | 0.641 | 1.287 | 0.587 | |||||||||
| Alcohol using status | No | 1 | |||||||||||
| Yes | 0.372 | 0.118 | 1.167 | 0.09 | |||||||||
| Mode of surgery | Elective | 1 | 1 | ||||||||||
| Emergent | 1.796 | 1.22 | 2.646 | 0.003 | 1.718 | 1.131 | 2.611 | 0.011 | |||||
| DM | No | 1 | |||||||||||
| Yes | 0.973 | 0.549 | 1.724 | 0.925 | |||||||||
| HT | No | 1 | |||||||||||
| Yes | 1.541 | 0.967 | 2.224 | 0.067 | |||||||||
| Histology | Adenocarcinoma | 1 | |||||||||||
| Mucinous adenocarcinoma | 1.207 | 0.793 | 1.839 | 0.38 | |||||||||
| Tumor grade | Well and moderately | 1 | |||||||||||
| Poorly | 1.574 | 0.889 | 2.787 | 0.119 | |||||||||
| Tumor location | RCC | 1 | |||||||||||
| LCC | 0.997 | 0.714 | 1.392 | 0.984 | |||||||||
| Tumor stage | II | 1 | 1 | ||||||||||
| III | 2.99 | 2.109 | 4.238 | < 0.001 | 2.281 | 1.485 | 3.505 | < 0.001 | |||||
| pT stage | T1 + 2 | 1 | < 0.001 | ||||||||||
| T2 | 1.912 | 0.999 | 3.662 | 0.05 | |||||||||
| T4 | 9.308 | 4.478 | 19.348 | < 0.001 | |||||||||
| Number of removed lymph nodes | ≥ 12 | 1 | 1 | ||||||||||
| < 12 | 2.166 | 1.421 | 3.301 | < 0.001 | 1.751 | 1.13 | 2.712 | 0.012 | |||||
| pN | N0 | 1 | < 0.001 | ||||||||||
| N1 | 2.779 | 1.908 | 4.047 | < 0.001 | |||||||||
| N2 | 3.56 | 2.237 | 5.664 | < 0.001 | |||||||||
| PNI | Negative | 1 | 1 | ||||||||||
| Positive | 3.953 | 2.801 | 5.578 | < 0.001 | 2.277 | 1.549 | 3.347 | < 0.001 | |||||
| LVI | Negative | 1 | 1 | ||||||||||
| Positive | 3.372 | 2.382 | 4.774 | < 0.001 | 1.825 | 1.221 | 2.728 | 0.003 | |||||
| Surgical margin | Negative | 1 | |||||||||||
| Positive | 3.884 | 1.436 | 10.505 | 0.008 | |||||||||
| Adjuvant treatment | No | 1 | 1 | ||||||||||
| Yes | 0.591 | 0.346 | 0.954 | 0.041 | 0.514 | 0.323 | 0.82 | 0.005 | |||||
DM: Diabetes mellitus; HT: Hypertension; Max: Maximum; Min: Minimum; LCC: Left colon cancer; LVI: Lymphovascular invasion; pN: Pathological lymph node stage; PNI: Perineural invasion; pT: Pathological tumor stage; RCC: Right colon cancer.