Table 4.
Factors affecting overall survival
|
Univariate analysis |
Multivariate analysis |
||||||||||||
| HR | 95%CI | P | HR | 95%CI | P | ||||||||
| Age (yr) | < 65 | 1 | 1 | ||||||||||
| ≥ 65 | 4.136 | 2.731 | 6.263 | < 0.001 | 4.049 | 2.578 | 6.358 | < 0.001 | |||||
| Gender | Male | 1 | |||||||||||
| Female | 0.951 | 0.636 | 1.423 | 0.808 | |||||||||
| Family history | No | 1 | |||||||||||
| Yes | 0.306 | 0.043 | 2.196 | 0.239 | |||||||||
| Smoking status | No | 1 | |||||||||||
| Yes | 0.815 | 0.533 | 1.247 | 0.346 | |||||||||
| Alcohol using status | No | 1 | |||||||||||
| Yes | 0.348 | 0.086 | 1.411 | 0.139 | |||||||||
| Mode of surgery | Elective | 1 | |||||||||||
| Emergent | 1.342 | 0.812 | 2.219 | 0.252 | |||||||||
| DM | No | 1 | |||||||||||
| Yes | 1.683 | 0.953 | 2.972 | 0.073 | |||||||||
| HT | No | 1 | |||||||||||
| Yes | 3.067 | 2.035 | 4.623 | < 0.001 | |||||||||
| Histology | Adenocarcinoma | 1 | |||||||||||
| Mucinous adenocarcinoma | 1.213 | 0.733 | 2.006 | 0.452 | |||||||||
| Tumor grade | Well and moderately | 1 | |||||||||||
| Poorly | 1.036 | 0.453 | 2.369 | 0.933 | |||||||||
| Tumor location | RCC | 1 | |||||||||||
| LCC | 0.807 | 0.539 | 1.208 | 0.297 | |||||||||
| Tumor stage | II | 1 | 1 | ||||||||||
| III | 2.363 | 1.57 | 3.557 | < 0.001 | 1.723 | 1.037 | 2.863 | 0.036 | |||||
| pT stage | T1 + 2 | 1 | < 0.001 | ||||||||||
| T2 | 4.836 | 1.526 | 15.326 | 0.007 | |||||||||
| T4 | 21.34 | 6.162 | 73.897 | < 0.001 | |||||||||
| Number of removed lymph nodes | ≥ 12 | 1 | |||||||||||
| < 12 | 1.402 | 0.897 | 2.192 | 0.138 | |||||||||
| pN | N0 | 1 | < 0.001 | ||||||||||
| N1 | 2.122 | 1.353 | 3.327 | 0.001 | |||||||||
| N2 | 3.015 | 1.742 | 5.219 | < 0.001 | |||||||||
| PNI | Negative | 1 | 1 | ||||||||||
| Positive | 3.653 | 2.4 | 5.562 | < 0.001 | 2.198 | 1.374 | 3.517 | 0.001 | |||||
| LVI | Negative | 1 | 1 | ||||||||||
| Positive | 3.735 | 2.445 | 5.707 | < 0.001 | 2.523 | 1.543 | 4.127 | < 0.001 | |||||
| Surgical margin | Negative | 1 | |||||||||||
| Positive | 2.57 | 0.633 | 10.435 | 0.187 | |||||||||
| Adjuvant treatment | No | 1 | 1 | ||||||||||
| Yes | 0.587 | 0.379 | 0.91 | 0.017 | 0.517 | 0.311 | 0.86 | 0.011 | |||||
DM: Diabetes mellitus; HT: Hypertension; LCC: Left colon cancer; LVI: Lymphovascular invasion; pN: Pathological lymph node stage; PNI: Perineural invasion; pT: Pathological tumor stage; RCC: Right colon cancer.