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Hypothetical distinct roles for apoptotic cell receptors in the homeostatic anti-inflammatory response versus allogenic tolerance. a Clearance of self-apoptotic cells (ACs) is known to induce anti-inflammatory signaling in macrophages, including cytokine IL-10. b Tolerogenic macrophage function may be stimulated by injection of donor-derived ACs, such as ECDI-SPs (see text), and may induce unique signaling downstream of apoptotic cell receptors
