Figure 2.
DKK1 levels in blood from patients with hematological disorders. (A) DKK1 plasma levels from patients diagnosed with FA (n = 98) or excluded from FA (BMF, n = 58) and as in Fig. 1 and from children suffering from various infections (n = 57) and from healthy blood donors (Control, n = 107). BMF represent patients with bone marrow failure presented as severe aplastic anemia or myelodysplasia that were excluded from FA at the time of diagnosis. Graphs represents the average of two separate determinations for each patient's sample. (B and C) DKK1 levels from FA (B) and BMF (C) patients according to age and gender. (D and E) DKK1 levels according to the FA gene mutated (in D) and age (in E). HC, healthy controls; ND, not determined. Statistical significance was determined by unpaired Student t‐test, linear regression (R 2) and Pearson's correlation.