Figure 4. Oridonin enhanced p53 expression by inhibition of Mdm2 in SNU-216 cells. SNU-216 cells were exposed to oridonin (0, 10, 40, and 80 μM) for 24 h. The protein (A) and mRNA (B) expressions of p53, and the protein expressions of p53 and Mdm2 (C) were determined by western blot. Data are reported as means±SD. *P<0.05, **P<0.01 compared to 0 μM (ANOVA).
