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. Author manuscript; available in PMC: 2018 Nov 21.
Published in final edited form as: Neuroscience. 2017 Jul 23;370:130–138. doi: 10.1016/j.neuroscience.2017.07.038

Fig. 2.

Fig. 2.

PXR−/− adult male mice show impaired recognition memory but intact coordination and motor learning. (A) Novel place recognition test. (B) Time of exploration of the novel location in PXR−/− mice. Data were analyzed using a two-way ANOVA: (Object exploration × Genotype: F(1,40) = 62.07, p < 0.0001). Specific comparisons: ***p < 0.001 (WT-new vs WT-familiar). (C) Discrimination index in PXR−/− mice (novel place recognition test). Data (mean ± SEM) were analyzed using Student’s t-test: ***p < 0.001. (D) Novel Object Recognition test. (E) Time of exploration of the novel object. Data were analyzed using a two-way ANOVA: (Object exploration × Genotype: F(1,40) = 86.40, p < 0.0001). Specific comparisons: ***p < 0.001 (WT-new vs WT-familiar). (F) Discrimination index in PXR−/− mice (novel object recognition test). Data (mean ± SEM) were analyzed using Student’s t-test: ***p < 0.001. (G) Coordination and motor learning over a training period of 3 days in PXR−/− mice (rotarod). Data were analyzed using a two-way ANOVA (Time × Genotype: F(2,60) = 1.48, P = 0.23; Time: F(2,60) = 20.47, p < 0.0001; Genotype: F(1,60) = 0.92, P = 0.34). n = 11 mice per group were used.