Table 1.

Preclinical models of cardiovascular disease in Lgals1^−/− mice.

Model	Effects	Mechanisms	Reference
AMI	Worse remodeling	Increased inflammation	[19]
HF	Spontaneous CMP	Increased inflammation	[19]
Chagas disease	Reduced cardiac inflammation and parasite infection	Not fully understood. Controversial results on survival	[52, 54]
PAH	Less PAH and reduced RV hypertrophy	Decreased vasoreactivity	[65]

AMI = acute myocardial infarction; HF = heart failure; PAH = pulmonary arterial hypertension; CMP = cardiomyopathy; RV = right ventricle.