Table 4.
Gene | SNP | Allele | Control | Moderate obese | Model 1a | Model 2b | Extreme obese | Model 1a | Model 2b | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 98.75%CI | P value | OR | 98.75%CI | p value | OR | 98.75%CI | P value | OR | 98.75%CI | p value | ||||||
UCP1 | rs1800592 | A | 227 | 271 | Ref | 172 | Ref | ||||||||||
G | 83 | 143 | 1.44 | 1.96–2.18 | 0.026 | 1.52 | 0.95–2.46 | 0.027 | 88 | 1.39 | 0.88–2.21 | 0.067 | 1.39 | 0.88–2.23 | 0.072 | ||
rs10011540 | T | 283 | 382 | Ref | 245 | Ref | |||||||||||
G | 27 | 32 | 0.87 | 0.44–1.73 | 0.633 | 1.01 | 0.46–2.23 | 0.967 | 15 | 0.64 | 0.28–1.48 | 0.183 | 0.58 | 0.25–1.37 | 0.113 | ||
rs3811791 | T | 298 | 378 | Ref | 246 | Ref | |||||||||||
C | 12 | 36 | 2.36 | 1.0–5.56 | 0.011 | 2.89 | 1.08–7.73 | 0.007 | 14 | 1.41 | 0.52–3.86 | 0.390 | 1.32 | 0.47–3.71 | 0.494 | ||
NPC1 | rs1805081 | T | 275 | 371 | Ref | 234 | Ref | ||||||||||
C | 35 | 43 | 0.91 | 0.50–1.66 | 0.698 | 0.78 | 0.39–1.56 | 0.376 | 26 | 0.87 | 0.44–1.73 | 0.619 | 0.86 | 0.43–1.75 | 0.612 | ||
rs1805082 | T | 225 | 306 | Ref | 185 | Ref | |||||||||||
C | 85 | 108 | 0.93 | 0.61–1.42 | 0.688 | 0.91 | 0.56–1.49 | 0.637 | 75 | 1.07 | 0.67–1.71 | 0.705 | 1.04 | 0.65–1.68 | 0.813 |
Data with significant p-value (< 0.0125) are shown in bold
aUnadjusted and bAdjusted for Age, Gender and T2DM