Table 3.
Comparison of mutational analysis in patients with YOFMF, AOFMF, and LOFMF (univariate analyses)
| Variable | YOFMF (n = 182) | AOFMF (n = 115) | LOFMF (n = 90) | p value | ||
|---|---|---|---|---|---|---|
| YOFMF vs AOFMF vs LOFMF | YOFMF vs others | Others vs LOFMF | ||||
| MEFV mutations (+) | 171/182 (94%) | 106/115 (92%) | 78/90 (87%) | 0.12 | 0.14 | 0.078 |
| Exon 1 mutations (+) | 11/182 (6%) | 6/115 (5%) | 0/90 (0%) | 0.064 | 0.15 | 0.016 |
| Exon 2 mutations (+) | 127/182 (70%) | 83/115 (72%) | 61/90 (68%) | 0.79 | 1.00 | 0.60 |
| Exon 3 mutations (+) | 22/182 (12%) | 14/115 (12%) | 15/90 (17%) | 0.54 | 0.65 | 0.29 |
| Exon 10 mutations (+) | 89/182 (49%) | 35/115 (30%) | 16/90 (18%) | < 0.0001 | < 0.0001 | < 0.0001 |
| Heterozygote mutations (+) | 22/182 (12%) | 13/115 (11%) | 5/90 (6%) | 0.23 | 0.32 | 0.11 |
| More than two MEFV mutations (+) | 125/182 (69%) | 65/115 (57%) | 41/90 (46%) | 0.0009 | 0.0009 | 0.0022 |
Number (percentage) presented. p values established using Fisher’s exact test or Mann–Whitney U test
YOFMF young-onset FMF, AOFMF adult-onset FMF, LOFMF late-onset FMF, FMF familial Mediterranean fever, MEFV Mediterranean fever gene