Table 1.
Comparison of the features of different ovarian stimulation protocol
| Protocol Year | Super long GnRH agonist | Standard long GnRH agonist | Short GnRH agonist | GnRH antagonist | Mild stimulation | Natural cycle |
|---|---|---|---|---|---|---|
| Percentage of different ovarian stimulation protocol (%) | ||||||
| 2012 | 4.38 | 58.31 | 22.57 | 8.30 | 4.93 | 1.51 |
| 2013 | 4.03 | 68.77 | 11.25 | 6.19 | 6.81 | 2.94 |
| 2014 | 4.71 | 62.65 | 13.51 | 4.95 | 10.23 | 3.95 |
| 2015 | 4.67 | 53.59 | 8.40 | 15.16 | 13.61 | 4.58 |
| 2016 | 6.24 | 43.69 | 4.60* | 26.39 | 12.89* | 4.65* |
| Number of retrieved oocytes | ||||||
| 2012 | 7.63 | 11.94 | 8.27 | 6.29 | 3.50 | 0.93 |
| 2013 | 9.99 | 11.42 | 7.69 | 6.42 | 2.80 | 0.82 |
| 2014 | 8.41 | 11.30 | 7.45 | 5.69 | 2.43 | 0.69 |
| 2015 | 10.87 | 11.04 | 7.23 | 6.31 | 2.32 | 0.72 |
| 2016 | 13.00 | 12.00 | 6.03* | 6.70 | 2.24* | 0.73 |
| Implantation rates (%) | ||||||
| 2012 | 27.53 | 31.58 | 22.22 | 17.65 | 12.26 | 18.60 |
| 2013 | 29.07 | 31.18 | 20.67 | 21.74 | 16.19 | 18.89 |
| 2014 | 33.64 | 33.17 | 23.71 | 20.86 | 15.06 | 22.73 |
| 2015 | 33.94 | 34.65 | 25.14 | 24.47 | 17.42 | 18.33 |
| 2016 | 31.21 | 34.60* | 25.58 | 25.11* | 17.01 | 21.97 |
| Clinical pregnancy rates (%) | ||||||
| 2012 | 45.59 | 48.56 | 33.42 | 29.27 | 18.34 | 26.03 |
| 2013 | 49.26 | 49.68 | 33.25 | 36.70 | 24.72 | 18.99 |
| 2014 | 53.63 | 49.77 | 37.58 | 35.22 | 22.85 | 21.30 |
| 2015 | 49.75 | 53.14 | 41.75 | 39.01 | 31.33 | 20.75 |
| 2016 | 49.44 | 52.90* | 42.32* | 39.41 | 25.69 | 22.73 |
| Early abortion rates (%) | ||||||
| 2012 | 12.44 | 11.79 | 14.79 | 19.74 | 24.66 | 26.32 |
| 2013 | 8.58 | 7.42 | 6.44 | 10.00 | 10.91 | 0.00 |
| 2014 | 9.41 | 10.68 | 9.98 | 15.52 | 15.38 | 8.70 |
| 2015 | 9.09 | 7.63 | 6.64 | 11.15 | 11.96 | 0.00 |
| 2016 | 8.63 | 8.53 | 11.31 | 9.05 | 14.88 | 16.00 |
| Ectopic pregnancy rates (%) | ||||||
| 2012 | 1.84 | 2.94 | 2.47 | 3.86 | 4.11 | 0.00 |
| 2013 | 4.29 | 2.40 | 4.46 | 10.50 | 3.64 | 13.33 |
| 2014 | 1.76 | 1.62 | 3.21 | 4.60 | 3.08 | 0.00 |
| 2015 | 1.35 | 2.29 | 3.65 | 2.69 | 0.48 | 4.55 |
| 2016 | 1.52 | 2.72 | 0.60 | 3.34 | 1.65 | 0.00 |
| Multiple pregnancy rates (%) | ||||||
| 2012 | 22.58 | 27.95 | 27.26 | 24.46 | 13.70 | 0.00 |
| 2013 | 32.62 | 26.09 | 24.01 | 24.00 | 18.18 | 13.33 |
| 2014 | 26.76 | 31.19 | 32.26 | 21.26 | 16.15 | 8.70 |
| 2015 | 35.35 | 31.48 | 31.23 | 22.12 | 6.70 | 4.55 |
| 2016 | 20.05 | 27.55 | 23.21 | 21.66 | 14.05 | 16.00 |
| Average dose of gonadotropin (IU) | ||||||
| 2012 | 3101.25 | 2356.5 | 2251.5 | 2379.75 | 1019.25 | 0 |
| 2013 | 3190.5 | 2541 | 2342.25 | 2201.25 | 945.75 | 9 |
| 2014 | 3342.75 | 2598 | 2406 | 2372.25 | 852.75 | 0 |
| 2015 | 3192 | 2560.5 | 2379 | 2419.5 | 913.5 | 9 |
| 2016 | 2678.25 | 2461.5 | 2418.75 | 2347.5 | 1176 | 37.5 |
*p < 0.05, represents a significant time trend in the each data from 2012 to 2016