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Biopsy of a distal tibia aneurysmal bone cyst in a 17-year-old girl pre-denosumab. (a) Abundant blood is present at periphery and giant cells in the context of high cellularity lesion rich in mononuclear cells in the central area. (b) Post-denosumab: disappearance of all mononucleated and multinucleated cells with trabecular and hyaline cells (denosumab-induced changes).
