Table 1.
T-cell subsets | Controls* versus patient | |||
---|---|---|---|---|
Severe lymphopenia | Lymphocyte reversal | |||
Blood | BALF | Blood | BALF | |
IFN-γ | ||||
CD4+ | 13.23 ± 1.49 versus 1.03 | 15.47 ± 4.72 versus 1.69 | 13.23 ± 1.49 versus 16.9 | 15.47 ± 4.72 versus 21.2 |
CD8+ | 23.43 ± 3.79 versus 0.82 | 33.33 ± 6.20 versus 1.06 | 23.43 ± 3.79 versus 30.3 | 33.33 ± 6.20 versus 36.1 |
IL-4 | ||||
CD4+ | 0.35 ± 0.07 versus 0.14 | 1.613 ± 0.54 versus 0.26 | 0.35 ± 0.07 versus 0.52 | 1.61 ± 0.54 versus 1.84 |
CD8+ | 0.71 ± 0.24 versus 0.21 | 1.66 ± 0.724 versus 0.18 | 0.71 ± 0.24 versus 0.71 | 1.66 ± 0.72 versus 1.58 |
IL-9 | ||||
CD4+ | 0.87 ± 0.28 versus 0.48 | 3.82 ± 0.77 versus 1.98 | 0.87 ± 0.28 versus 1.46 | 3.82 ± 0.77 versus 11.6 |
CD8+ | 1.03 ± 0.13 versus 0.34 | 4.45 ± 0.74 versus 0.82 | 1.03 ± 0.13 versus 1.34 | 4.45 ± 0.74 versus 11.1 |
IL-17 | ||||
CD4+ | 1.12 ± 0.36 versus 0.32 | 1.96 ± 1.00 versus 0.51 | 1.12 ± 0.36 versus 1.10 | 1.96 ± 1.00 versus 3.11 |
CD8+ | 0.75 ± 0.18 versus 0.14 | 1.59 ± 0.76 versus 0.19 | 0.75 ± 0.18 versus 1.56 | 1.59 ± 0.76 versus 2.55 |
PD-1 | ||||
CD4+ | 14.6 ± 1.12 versus 40.2 | 17.4 ± 1.19 versus 45.5 | 14.6 ± 1.12 versus 23.1 | 17.4 ± 1.19 versus 31.1 |
CD8+ | 13.8 ± 3.29 versus 30.0 | 17.6 ± 2.25 versus 35.6 | 13.8 ± 3.29 versus 17.3 | 17.6 ± 2.25 versus 25.4 |
Treg | 7.10 ± 0.48 versus 1.11 | 10.4 ± 3.16 versus 2.54 | 7.10 ± 0.48 versus 10.3 | 10.4 ± 3.16 versus 11.2 |
*Data of the healthy donors (n = 3) are presented as mean ± SD. BALF: Bronchoalveolar lavage fluid; IFN-γ: Interferon-γ; IL-4: Interleukin-4; IL-9: Interleukin-9; IL-17: Interleukin-17; PD-1: Programmed cell death-1; Treg: Regulatory T-cell; SD: Standard deviation.