Table 4.

Multivariable Analysis of Factors Associated With Clinical Outcomes

Effect	Point Estimate of Odds Ratio (OR)	95% Confidence Interval for OR
Mortality
Ceftolozane-tazobactam started >4 days after culture	5.55	2.14–14.40
Age ≥60	0.20	0.07–0.57
Charlson Comorbidity Index (each 1 point)	1.24	1.01–1.52
Vasopressor use	5.68	2.15–14.98
APACHE II score (each 1 point)	1.14	1.08–1.22
Clinical success
Ceftolozane-tazobactam started ≤4 days after culture	2.93	1.40–6.10
Vasopressor use	0.16	0.070–0.344
APACHE II score (each 1 point)	0.95	0.91–0.99
Microbiological cure
Ceftolozane-tazobactam started ≤4 days after culture	2.59	1.24–5.38
Concomitant antibiotic use	0.26	0.13–0.54
Pneumonia	0.12	0.05–0.30
Vasopressor use	0.33	0.15–0.73

Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; OR, odds ratio.