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. 2018 Nov 14;10:365. doi: 10.3389/fnagi.2018.00365

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Copyright © Amoroso, La Rocca, Bruno, Maggipinto, Monaco, Bellotti, and Tangaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Brain morphological changes occur in localized regions and affect the spatial distribution of gray level intensities. For example, atrophy increases the cerebrospinal fluid (CSF) volume at the expenses of gray matter (GM) in panel. (B) Pearson's correlation of these two patches is computed against: (1) a patch with a symmetric distribution of GM and CSF; (2) an anti-symmetric patch mimicking left-right inversion; (3) a pure GM patch; (4) a pure CSF patch. (C) In atrophic brains (red) connections (1) and (2) disappear (dotted lines) while they remain strong connections in normal brains (blue).