Table 3.
Top detoxification genes upregulated in RDDT-S, Rperm-S and C-S
| Probe name | Systematic name | RDDT-S fold change (FC) | Rperm-S fold change (FC) | C-S fold change (FC) | Ortholog in An. gambiae | Description |
|---|---|---|---|---|---|---|
| CUST_500_PI426302897 | Afun000500 | 36.2 | 38.1 | 41.4 | na | Glycogenin |
| CUST_9227_PI426302897 | Afun009227 | 22.2 | 23.3 | 25.6 | AGAP008141-PA | Argininosuccinate lyase |
| CUST_45_PI426302897 | Afun000045 (GSTE2) | 13.3 | 10.9 | 15.2 | AGAP009194-PA | Glutathione-S-transferase |
| CUST_4223_PI426302897 | Afun004223 | 12.8 | 10.6 | 9.4 | AGAP008358-PA | Cytochrome p450 4d1 |
| CUST_9697_PI426302897 | Afun009697 | 11.6 | 4.8 | 6.8 | AGAP006364-PA | Abc transporter |
| CUST_1822_PI406199769 | combined_c920 | 11.5 | 11.1 | 11.4 | Glutathione-S-transferase | |
| CUST_3220_PI426302897 | Afun003220 | 10.8 | 5.7 | 7.0 | AGAP002867-PA | Cytochrome p450 |
| CUST_9492_PI426302897 | Afun009492 | 7.9 | 16.4 | 3.7 | AGAP001722-PA | Carboxylesterase |
| CUST_8615_PI426302897 | Afun008615 (CYP6AA1 ) | 5.1 | 5.2 | 3.8 | AGAP002862-PA | Cytochrome p450 |
| CUST_9_PI426302915 | CYP6M4.seq | 4.9 | 4.8 | 3.5 | Cytochrome p450 | |
| CUST_8445_PI426302897 | Afun008445 (GSTE4) | 4.3 | 3.9 | 4.7 | AGAP009193-PA | Glutathione-S-transferase |
| CUST_6930_PI426302897 | Afun006930 (CYP6M7) | 4.0 | 34.6 | 28.9 | AGAP008212-PA | Cytochrome p450 6a8 |
| CUST_25_PI426302915 | CYP6Y2_rvcpl.seq | 3.4 | 3.7 | 3.8 | Cytochrome p450 | |
| CUST_20_PI426302915 | CYP6S1.seq | 3.0 | 2.3 | 2.2 | Cytochrome p450 | |
| CUST_8909_PI426302897 | Afun008909 (CYP4K2) | 2.8 | 2.4 | 2.0 | AGAP002416-PA | Cytochrome p450 |
| CUST_1392_PI426302897 | Afun001392 | 2.5 | 3.3 | 3.4 | na | Glycine dehydrogenase |
| CUST_13218_PI426302897 | Afun013218 (CYP315A1) | 2.3 | 2.9 | 2.6 | AGAP000284-PA | Cytochrome p450 |
| CUST_7499_PI426302897 | Afun007499 (GSTD1) | 2.2 | 2.0 | 2.6 | AGAP004164-PA | Glutathione transferase |
| CUST_11037_PI426302897 | Afun011037 | 6.5 | 3.7 | AGAP003581-PA | Alcohol dehydrogenase | |
| CUST_12343_PI426302897 | Afun012343 (CYP4H18 ) | 5.2 | 5.0 | AGAP008358-PA | Cytochrome p450 4d1 | |
| CUST_10836_PI426302897 | Afun010836 | 4.3 | 4.8 | AGAP006228-PA | Esterase b1 | |
| CUST_7769_PI426302897 | Afun007769 (CYP9K1 ) | 3.0 | 2.2 | AGAP000818-PA | Cytochrome p450 cyp9k1 | |
| CUST_7469_PI426302897 | Afun007469 (CYP9J3) | 2.0 | 2.1 | AGAP012296-PA | Cytochrome p450 | |
| CUST_12461_PI426302897 | Afun012461 | 8.4 | 10.9 | AGAP000288-PA | Alcohol dehydrogenase | |
| CUST_3489_PI406199769 | combined_c1762 | 2.2 | 2.2 | Abc transporter | ||
| CUST_8026_PI426302897 | Afun008026 | 2.1 | 2.2 | AGAP003578-PA | Aldehyde dehydrogenase | |
| CUST_1458_PI406199769 | combined_c738 | 10.4 | 15.9 | Short-chain dehydrogenase | ||
| CUST_4043_PI406199772 | CD577345.1 | 4.4 | 3.7 | Cuticle protein | ||
| CUST_15331_PI426302897 | Afun015331 (CYP307A1) | 3.4 | 2.2 | AGAP001039-PB | Cytochrome p450 307a1 | |
| CUST_25_PI406199775 | CYP6P9a | 2.8 | 2.3 | Cytochrome p450 | ||
| CUST_13481_PI426302897 | Afun013481 (GSTE1 ) | 2.5 | 2.7 | AGAP009195-PA | Glutathione-S-transferase gst | |
| CUST_4048_PI406199772 | CD577343.1 | 5.3 | Cuticle protein | |||
| CUST_11042_PI426302897 | Afun011042 | 3.9 | AGAP003321-PA | Glycine dehydrogenase | ||
| CUST_1_PI426302915 | CYP6M1a.seq | 2.9 | Cytochrome p450 | |||
| CUST_9335_PI426302897 | Afun009335 (CYP6AG1) | 2.4 | AGAP003343-PA | Cytochrome p450 | ||
| CUST_13475_PI426302897 | Afun013475 | 3.2 | AGAP003582-PA | Alcohol dehydrogenase | ||
| CUST_5448_PI426302897 | Afun005448 (CYP302A1) | 2.6 | AGAP005992-PA | Cytochrome p450 | ||
| CUST_4047_PI406199772 | CD577343.1 | 2.4 | Cuticle protein | |||
| CUST_8823_PI426302897 | Afun008823 (CYP4D15 ) | 2.4 | AGAP002418-PA | Cytochrome p450 | ||
| CUST_7301_PI426302897 | Afun007301 (CYP4J5) | 2.2 | AGAP006048-PA | Cytochrome p450 | ||
| CUST_208_PI406199788 | gb-CYP12F3 | 2.1 | Cytochrome p450 | |||
| CUST_10630_PI426302897 | Afun010630 | 2.1 | AGAP002866-PA | Cytochrome p450 | ||
| CUST_7722_PI426302897 | Afun007722 | 3.2 | AGAP009850-PA | Abc transporter | ||
| CUST_12261_PI426302897 | Afun012261 | 2.8 | AGAP005758-PA | Carboxylesterase | ||
| CUST_4088_PI406199772 | CD577323.1 | 2.4 | Cuticle protein | |||
| CUST_493_PI426302897 | Afun000493 | 2.1 | AGAP006225-PA | Aldehyde oxidase |
Abbreviation: na not available