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. 2018 Nov 20;20:143. doi: 10.1186/s13058-018-1070-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Chronological steps of lymph node metastasis (H&E stain). a An uninvolved axillary LN with no evidence of tumour cells (0.7×). b Partial colonisation of a LN with significant amount of residual uninvolved LN tissue (black arrowhead) and two nodules of metastasis (black arrows) are depicted (0.5×). Inset shows tumour cells mixed with background immune cells (20×). c A lymph node with near total replacement of normal lymph nodal tissue (1×). The inset displays a higher power magnification of tumour cells (10×). All images were captured by Nanozoomer and viewed in NDP.view2 software (Hamamatsu)