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. 2018 Nov 14;9:1273. doi: 10.3389/fphar.2018.01273

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Copyright © 2018 Pirault and Bäck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Receptors and ligands for lipoxin and resolvin receptors. Lipoxin A₄ is derived from arachidonic acid, whereas D- and E- series resolvins are formed from metabolism of the omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), respectively. There are currently four known lipoxin and resolvin receptors; ALX/FPR2 for lipoxin A₄ and resolvin D1; DRV1/GPR32 for resolvin D1; DRV2/GPR18 for resolvin D2; and ERV1/ChemR23 for resolvin E1.