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. 2018 Nov 14;9:1273. doi: 10.3389/fphar.2018.01273

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Copyright © 2018 Pirault and Bäck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resolvin E1 signaling through ERV1/ChemR23. The proresolving mediator resolvin E1 (RvE1) stimulates phagocytosis and decreases inflammation and uptake of oxidized low density lipoprotein (oxLDL) in macrophages, which contribute to reduced atherosclerosis. RvE1-induced effects on polymorphonuclear neutrophil granulocytes (PMN) and cardiomyocytes are also shown. Chemerin mediates chemotactic effects through ERV1/ChemR23.