Table 1.
Baseline characteristics of study subjects
| Parameter | Calcitriol-treatment (mean±SD) | Placebo (mean±SD) | P-value |
|---|---|---|---|
|
| |||
| Age, years | 58.2±8.1 | 57.1±8.2 | 0.65 |
| Height, m | 154.6±5.2 | 156.2±6.1 | 0.27 |
| Weight, kg | 64.5±6.2 | 66.4±7.8 | 0.07 |
| BMI, kg/m2 | 24.3±3.1 | 23.5±3.2 | 0.52 |
| BMD, g/cm2 (L1–4) | 0.788±0.10 | 0.813±0.28 | 0.66 |
| BMD, g/cm2 (FN) | 0.636±0.08 | 0.645±0.13 | 0.64 |
| BMD, g/cm2 (total hip) | 0.786±0.10 | 0.719±0.10 | 0.49 |
| ASMI, kg/m2 | 6.18±0.73 | 5.95±0.69 | 0.07 |
| FGF-23, pg/mL | 101.7±46.0 | 120.55±52.6 | 0.31 |
| SOST, pg/mL | 103.4±28.0 | 118.79±24.7 | 0.29 |
| PTH, pg/mL | 44.78±15.5 | 47.0±21.1 | 0.08 |
| 25(OH)2D, ng/mL | 17.10±7.8 | 15.8±9.6 | 0.22 |
| CTX, pg/mL | 416.2±125.8 | 393.26±132.1 | 0.47 |
| BGP, ng/mL | 18.7±4.8 | 20.3±7.1 | 0.30 |
| ALP, IU/L | 82.9±20.7 | 78.6±22.9 | 0.32 |
| Blood glucose, mmol/L | 6.02±1.0 | 5.8±1.2 | 0.29 |
| UA, mmol/L | 291.3±56.4 | 314.5±76.3 | 0.19 |
| TC, mmol/L | 5.6±0.8 | 5.2±0.9 | 0.054 |
| TG, mmol/L | 1.5±0.6 | 2.3±1.7 | 0.066 |
| Serum Ca, mmol/L | 2.44±0.08 | 2.37±0.19 | 0.32 |
| Serum P, mmol/L | 1.30±0.13 | 1.18±0.17 | 0.28 |
| Urinary Ca, mmol | 4.32±1.8 | 4.58±2.3 | 0.15 |
| Serum Cr, mmol/L | 60.3±9.3 | 64.5±11.6 | 0.61 |
| GFR, mL/kg⋅s | 110.2±23.5 | 115±22.7 | 0.53 |
| Grip (left), kg | 19.95 (17.75–22.0) | 19.57 (17.0–22.0) | 0.31 |
| Grip (right), kg | 21.70 (18.0–25.0) | 21.86 (18.0–25.25) | 0.66 |
Note: Data are presented as mean±SD or median (25th–75th percentile).
Abbreviations: 25(OH)2D, serum 1,25-dihydroxyvitamin D; ASMI, appendicular skeletal mass index; BGP, bone Gla protein or osteocalcin; BMD, bone mineral density; BMD (L1–4), BMD of lumbar vertebrae 1–4; BMD (FN), BMD of femur neck; BMD (total hip), BMD of total hip; BMI, body mass index; Cr, creatinine; CTX, cross-linked C-terminal telopeptide of type I collagen; FGF-23, fibroblast growth factor-23; GFR, glomerular filtration rate; Grip (left), grip strength of left hand; Grip (right), grip strength of right hand; PTH, parathyroid hormone; SOST, sclerostin; TC, total cholesterol; TG, triglyceride; UA, uric acid; Urinary Ca, 24-hour urinary calcium.