Table 2.
Changes in biochemical parameters and markers of bone turnover between baseline and 12 weeks
| Placebo (n=66) | Calcitriol (n=75) | Between-group difference (compared to placebo group) | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| Mean change (95% CI) | P-value | Mean change (95% CI) | P-value | Difference of mean changes (95% CI) | P-value | |
|
| ||||||
| BMI | −0.30 (−1.46 to 0.87) | 0.61 | 0.32 (−0.88 to 1.52) | 0.60 | 1.84 (−0.65 to 3.23) | 0.33 |
| Grip strength (left), kg | −0.871 (−0.425 to 0.666) | 0.384 | 2.96 (1.29 to 3.04) | 0.019 | 2.12 (1.87 to 2.36) | 0.03 |
| Grip strength (right), kg | −0.255 (−0.13 to 0.328) | 0.799 | 1.953 (−0.044 to 2.025) | 0.051 | 1.81 (−0.71 to 1.99) | 0.070 |
| ASMI, kg/m2 | 0.02 (−0.22 to 0.26) | 0.86 | −0.06 (−13.28 to 37.89) | 0.62 | 0.56 (−0.27 to 0.84) | 0.23 |
| FGF-23, pg/mL | −5.92 (−1.99 to 13.83) | 0.14 | −6.77 (−27.3 to 13.79) | 0.51 | −8.36 (−12.21 to 25.77) | 0.65 |
| SOST, pg/mL | 0.19 (−0.42 to 0.81) | 0.53 | −5.91 (−22.0 to −3.75) | 0. 016 | −7.05 (−19.8 to −2.75) | 0.039 |
| PTH, pg/mL | 5.49 (−5.01 to 15.99) | 0.29 | −7.79 (−11.13 to −4.44) | 0.000 | −8.08 (−10.55 to −5.38) | 0.035 |
| 25(OH)2D, ng/mL | 0.10 (−3.16 to 3.36) | 0.95 | −1.89 (−3.17 to 0.60) | 0.25 | 5.25 (−2.37 to 8.14) | 0.68 |
| CTX, pg/mL | −18.39 (−98.56 to 61.77) | 0.64 | 18.31 (−14.82 to 51.44) | 0.27 | −19.98 (−95.05 to 55.04) | 0.596 |
| BGP, ng/mL | 3.74 (−0.37 to 7.87) | 0.07 | −0.47 (0.27 to −1.25) | 0.21 | −1.94 (−4.38 to 0.50) | 0.117 |
| ALP, IU/L | −4.27 (−5.24 to 1.29) | 0.21 | −7.03 (−10.25 to −3.81) | 0.03 | −5.17 (−12.87 to 2.54) | 0.45 |
| Blood glucose, mmol/L | 0.05 (−0.85 to 0.94) | 0.09 | −0.35 (−0.53 to −0.17) | 0.045 | 0.01 (−0.61 to 0.87) | 0.727 |
| UA, mmol/L | −27.98 (−81.5 to 25.53) | 0.29 | 20.23 (8.91 to 31.53) | 0.001 | 7.89 (2.2 to 13.99) | 0.032 |
| Serum Cr, mmol/L | 2.03 (−4.07 to 8.12) | 0.59 | 3.92 (2.41 to 5.42) | 0.000 | 2.00 (1.08 to 5.09) | 0.027 |
| TC, mmol/L | 4.85 (−6.87 to 16.57) | 0.38 | 0.10 (−0.09 to 0.30) | 0.298 | −0.40 (−0.89 to 0.08) | 0.101 |
| TG, mmol/L | 17.27 (−20.39 to 54.95) | 0.33 | −0.19 (−0.33 to 0.05) | 0.07 | 0.48 (−0.02 to 0.94) | 0.061 |
| Serum Ca, mmol/L | −0.04 (−0.08 to 0.015) | 0.16 | 0.02 (−0.003 to 0.04) | 0.09 | −0.03 (−0.65 to 0.01) | 0.064 |
| Serum P, mmol/L | 0.91 (−0.93 to 2.75) | 0.32 | 0.05 (−0.01 to 0.08) | 0.11 | −0.08 (−0.14 to 0.02) | 0.36 |
| Urinary Ca, mmol | 1.92 (−1.99 to 13.83) | 0.15 | 1.51 (0.83 to 2.19) | 0.000 | 2.78 (1.10 to 3.05) | 0.026 |
Note: Data are presented as mean change and 95% CI.
Abbreviations: 25(OH)2D, serum 1,25-dihydroxyvitamin D; ASMI, appendicular skeletal mass index; BGP, bone Gla protein or osteocalcin; BMD, bone mineral density; BMD (L1–4), BMD of lumbar vertebrae 1–4; BMD (FN), BMD of femur neck; BMD (total hip), BMD of total hip; BMI, body mass index; Cr, creatinine; CTX, cross-linked C-terminal telopeptide of type I collagen; FGF-23, fibroblast growth factor-23; GFR, glomerular filtration rate; Grip (left), grip strength of left hand; Grip (right), grip strength of right hand; PTH, parathyroid hormone; SOST, sclerostin; TC, total cholesterol; TG, triglyceride; UA, uric acid; Urinary Ca, 24-hour urinary calcium.