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Biochemical analyses confirmed amelioration of metabolic disease in transplanted mice. Plasma from the time of sacrifice (6 months post transplantation) in all transplanted mice (n = 6) was compared to plasma of Fah−/− untreated controls off NTBC (–NTBC; n = 5) and untreated Fah−/− mice on NTBC (+NTBC; n = 5). ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin. ***p < 0.001; ****p < 0.0001.
