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. 2018 Nov 12;35(23):2837–2849. doi: 10.1089/neu.2018.5660

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© Johanna Flygt et al., 2018; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 5. — Microglia/macrophage morphology is altered by IL-1β neutralization. Sholl analysis showed changes in microglia/macrophage morphology between the different treatment groups (sham CsA, Sham IL-1β, cFPI CsA, and cFPI IL-1β) and time points (2, 7, and 14 dpi). (A) At two dpi, microglia/macrophages of cFPI IL-1β animals appeared more active compared with other groups with a lower number of intersections and increasing number of Sholl circles. (B) At seven dpi, microglia/macrophage of sham IL-1β animals were more active compared with other groups. At 14 dpi (C), microglia/macrophages of sham IL-1β and brain-injured animals showed the same level of activation as brain-injured animals, and microglia/macrophages of sham CsA animals were more ramified indicated by an increased number of intersections with increasing number of Sholl circles. When intersections at different intervals from the cell center were analyzed, microglia/macrophages of sham IL-1β animals appeared less active at two dpi (D), although became more active at seven dpi (E) compared with microglia/macrophages of other groups. At 14 dpi (F), microglia/macrophages of sham IL-1β animals and microglia of brain-injured animals displayed the same level of activation. Thus, the microglia/macrophages of sham CsA animals were more ramified. Graphs are presented as mean and standard error of the mean. cFPI, central fluid percussion injury; dpi, days post-injury; CsA, inactive control antibody against cyclosporin A; IL-1β, interleukin 1 beta.