Table 2.
Perioperative variables according to early postoperative mean arterial blood pressure.
| MBPover90 (n=567) | MBPbelow90 (n=569) | Total (n=1136) | P value | |
|---|---|---|---|---|
| Perioperative MBP | ||||
| Preoperative MBP | 85.6±9.4 | 79.2±8.4 | 82.4±9.5 | <0.001 |
| Early postoperative MBP | 97.3±5.2 | 83.0±5.1 | 90.2±8.8 | <0.001 |
| Increase in MBP after surgery | 12.7 [5.2; 18.9] | 4.9 [–1.9; 10.3] | 8.3 [0.9; 14.7] | <0.001 |
| Demographics | ||||
| Age (years) | 51.8±8.1 | 54.2±7.8 | 53.0±8.0 | <0.001 |
| Sex, male | 453 (79.9%) | 406 (71.4%) | 859 (75.6%) | 0.001 |
| Body mass index (kg/m2) | 24.2±3.1 | 24.0±3.6 | 24.1±3.4 | 0.100 |
| Diabetes mellitus | 98 (17.3%) | 131 (23.0%) | 229 (20.2%) | 0.019 |
| Hypertension | 79 (13.9%) | 47 (8.3%) | 126 (11.1%) | 0.003 |
| Heart rate | 72.5±11.2 | 72.9±11.8 | 72.7±11.5 | 0.636 |
| MELD score | 13.1±6.6 | 14.0±6.3 | 13.6±6.5 | <0.001 |
| Preoperative vasopressor use | 24 (4.2%) | 20 (3.5%) | 44 (3.9%) | 0.636 |
| Donor age | 27.4±8.6 | 28.6 ±8.3 | 28.0±8.4 | 0.023 |
| Hypertension medication | ||||
| Angiotensin II receptor antagonist | 40 (7.1%) | 28 (4.9%) | 68 (6.0%) | 0.164 |
| Angiotensin-converting-enzyme inhibitor | 2 (0.4%) | 1 (0.2%) | 3 (0.3%) | 0.998 |
| Calcium channel blocker | 67 (11.8%) | 47 (8.3%) | 114 (10.0%) | 0.058 |
| Beta blockers | 80 (14.1%) | 89 (15.6%) | 169 (14.9%) | 0.521 |
| Etiology of liver cirrhosis | ||||
| Hepatitis B virus | 361 (63.7%) | 329 (57.8%) | 690 (60.7%) | 0.050 |
| Hepatitis C virus | 38 (6.7%) | 49 (8.6%) | 87 (7.7%) | 0.272 |
| Alcohol abuse | 105 (18.5%) | 102 (17.9%) | 207 (18.2%) | 0.856 |
| Biliary cirrhosis | 12 (2.3%) | 28 (4.9%) | 41 (3.6%) | 0.027 |
| Others | 61 (10.8%) | 74 (13.0%) | 135 (11.9%) | 0.281 |
| Preoperative laboratory variables | ||||
| Creatinine (mg/dL) | 0.7±0.2 | 0.7±0.2 | 0.7±0.2 | 0.017 |
| Cystatin C GFR (ml/min/1.73 m2) | 107.9±31.2 | 103.9±32.5 | 105.9±31.9 | 0.011 |
| Albumin (g/dL) | 3.2±0.6 | 3.1±0.5 | 3.2±0.6 | <0.001 |
| Total bilirubin (mg/dL) | 4.4±7.8 | 4.7±7.8 | 4.5±7.8 | 0.022 |
| Perioperative variables | ||||
| Transfused pRBC (Units) | 5 [0; 10] | 6 [2; 12] | 5 [1; 10] | 0.006 |
| Intraoperative vasopressor uses | 510 (89.9%) | 541 (95.1%) | 1051 (92.5%) | 0.002 |
| Severe post-reperfusion syndrome | 50 (8.8%) | 75 (13.2%) | 125 (11.0%) | 0.024 |
| Graft-to-recipient weight ratio | 1.1±0.2 | 1.1±0.3 | 1.1±0.2 | 0.381 |
| Total ischemic time (min) | 128.9±45.2 | 130.9±30.9 | 129.9±38.7 | 0.071 |
| Postoperative vasopressor use (days) | 0 [0; 0] | 0 [0; 1] | 0 [0; 1] | <0.001 |
| Use of FK506 | 518 (91.4%) | 4.5±39.4 | 1025 (90.2%) | 0.120 |
| Trough level of FK506 (ng/mL) | 6.2±2.4 | 507 (89.1%) | 6.2±2.5 | 0.238 |
| Outcome variables | ||||
| Acute kidney injury | 355 (62.6%) | 422 (74.2%) | 777 (68.4%) | <0.001 |
| Grade 1 | 227 (40.0%) | 239 (42.05) | 466 (41.0%) | 0.539 |
| Grade 2 | 95 (16.8%) | 138 (24.3%) | 233 (20.5%) | 0.002 |
| Grade 3 | 33 (5.8%) | 45 (7.9%) | 78 (6.9%) | 0.202 |
| 3-month CKD | 18 (3.2%) | 19 (3.3%) | 37 (3.3%) | 1.000 |
| Overall CKD | 115 (20.3%) | 122 (21.4%) | 237 (20.9%) | 0.684 |
| Hospital stay (days) | 30 [24;41] | 31 [24;47] | 30 [24;44] | 0.108 |
| Intensive care unit stay (days) | 3 [2; 4] | 3 [2; 5] | 3 [2; 5] | 0.002 |
Values are expressed as mean±SD, median [IQR], or numbers (percent). MBP – mean arterial blood pressure; MELD – model for end-stage liver disease; GFR – glomerular filtration rate; pRBC – packed red blood cells; CKD – chronic kidney injury.