Table 6. Non-teratogenic structural analogues of thalidomide; compounds in which both phthalimide and glutarimide functions have been replaced.

Name	Systematic name	Structure	Test species and references
2-(3-Oxo-1,2-benzisothiazolin-2-yl)succinimide-S,S-dioxide [49]	3-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)pyrrolidine-2,5-dione		Rabbit47
[50]	2-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)acetamide		Rabbit47
[51]	2-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)butanamide		Rabbit47
[52]	2-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)acetamide		Rabbit47
4-Oxo-3(4H)-quinazolineacetamide [53]	2-(4-Oxoquinazolin-3(4H)-yl)acetamide		Rabbit47
2-(4-Oxo-3,4-dihydroquinazolin-3-yl)-succinimide [54]	3-(4-Oxoquinazolin-3(4H)-yl)pyrrolidine-2,5-dione		Rabbit47
α-Ethyl-4-oxo-3(4H)-quinazolineacetamide [55]	2-(4-Oxoquinazolin-3(4H)-yl)butanamide		Rabbit47
CG3033 supidimide 3-(2,3-dihydro-1,1-dioxido-3-oxo-1,2-benzisothiazol-2-yl)-2-oxopiperidine [56]	2-(2-Oxopiperidin-3-yl)-1,2-benzothiazol-3(2H)-one 1,1-dioxide		Baboon37,54
			Rabbit46
EM240 [57]	2-[(2-Oxopiperidin-3-yl)sulfamoyl]benzoic acid		Rhesus monkey53
Phthalamudine 3-(4′-chloro-3′-sulphmoyl)-3-hydroxy-phthalimidine [58]	2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide		Rabbit51
Captan N-(trichloromethylthio) –Δ4-tetrahydrophthalimide [59]	2-[(Trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione		Rabbit51