Table 3. Survival Trajectories and Causes of Death for Risk Clusters.
| Risk Cluster | Median (PR) | Cancer Types | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Survival, y | High-Risk Period, y | Mortality Gap, % | Cause of Death % of At-Risk Population | Metastatic Spread,a % | ||||||
| Primary Cancer | Secondary Cancer | Cardiac | Other | Localized | Distant | |||||
| 1 | 16.2 (10.7-40.2) | 2.5 (0-5.0) | 1.4 (0.3-2.4) | 6.7 (1.2-18.0) | 10.1 (5.0-27.0) | 8.8 (0.5-16.1) | 15.1 (5.1-23.7) | 83.8 (47.7-95.5) | 5.7 (1.1-45.8) | Lip, skin, breast, vagina/labia, vulva, cervix, uterus, placenta, penis/scrotum, prostate, testis, epididymis/spermatic cord/male genital NOS, orbit/lacrimal gland, retina, eyeball, thyroid, parathyroid, pituitary |
| 2 | 8.3 (5.1-23.3) | 6.0 (4.0-8.0) | 2.5 (0.9-4.6) | 19.1 (4.0-30.0) | 18.2 (5.3-35.8) | 6.9 (1.2-14.4) | 14.1 (8.1-22.2) | 66.1 (0-86.0) | 13.1 (0.1-44.0) | Tongue, gum/mouth floor, salivary gland, oropharynx, nasopharynx, small intestine, colon, appendix, rectum, anus, nasal cavity, larynx, thymus, mediastinum, bones/joints, spleen, connective soft tissue, other female genitals, kidney, ureter/renal pelvis, urinary bladder, other urinary organs, eye NOS, meninges, ventricle, cerebellum, pineal gland |
| 3 | 2.8 (1.4-3.7) | 7.0 (6.0-11.1) | 2.1 (1.3-3.7) | 30.8 (6.5-47.8) | 30.7 (8.0-45.9) | 4.1 (2.8-6.0) | 9.6 (6.9-20.4) | 31.5 (0-48.7) | 34.4 (1.0-62.6) | Middle ear accessory muscles, retroperitoneum/peritoneum, uterus NOS, ovary, other nervous system, adrenal glands, ill-defined |
| 4 | 1.6 (1.5-1.8) | 6.0 (5.1-11.4) | 6.1 (4.0-9.0) | 18.3 (15.5-23.7) | 42.6 (40.4-52.6) | 7.3 (7.2-7.8) | 14.2 (9.8-15.2) | 62.1 (50.9-72.5) | 21.3 (15.2-31.7) | Hypopharynx, pharynx, trachea |
| 5 | 0.8 (0.5-1.2) | 9.0 (6.3-16.9) | 2.4 (1.1-6.0) | 56.8 (19.8-71.2) | 12.4 (4.5-56.0) | 4.3 (1.8-6.2) | 8.9 (8.3-12.7) | 49.2 (2.1-65.2) | 29.0 (5.9-68.1) | Esophagus, stomach, liver, gallbladder, unspecified digestive organs, lung/bronchus, heart, brain/central nervous system/spine |
| 6 | 0.5 (0.4-0.8) | 12.0 (9.3-12.9) | 3.0 (1.1-4.2) | 54.5 (19.4-78.8) | 29.0 (7.5-65.4) | 2.1 (1.7-2.5) | 5.7 (4.8-6.5) | 38.0 (24.1-46.7) | 48.7 (32.5-59.2) | Intrahepatic bile ducts, pancreas, pleura |
Abbreviations: NOS, not otherwise specified; PR, 5th-95th percentile range.
a
Unstaged cancers are not reported in the Metastatic Spread columns.