Table 3. Linear Relationship in Activation Across 16 Participants at Clinical High Risk of Psychosis Receiving Placebo, 19 Healthy Controls, and 15 Participants Receiving Cannabidiol (CBD).

Region	Coordinates of Peak (TAL)			Cluster Size, No. of Voxels	P Valuea
	X	Y	Z
Verbal Encoding
Placebo > CBD > control
Inferior frontal gyrus extending to middle frontal gyrus and insula	40	37	10	135	<.001
Insula extending to putamen	−36	11	10	112	<.001
Precentral gyrus	−40	−11	30	39	.004
Precentral gyrus	−51	−4	16	34	.003
Precentral gyrus	40	−11	39	124	<.001
Fusiform gyrus extending to cerebellum	43	−44	−13	53	.003
Cerebellum extending to fusiform gyrus	−22	−52	−16	100	<.001
Placebo < CBD < control
Caudate head extending to anterior	−14	22	0	44	.004
Subcallosal gyrus/caudate head	14	11	−10	87	.001
Caudate tail extending to posterior cingulate	18	−37	13	65	.004
Precuneus extending to cuneus	4	−63	30	185	<.001
Verbal Recall
Placebo > CBD > control
Inferior frontal gyrus extending to middle frontal gyrus and insula	47	11	23	120	<.001
Precuneus extending to cuneus, lingual, middle occipital, and fusiform gyri and cerebellum	25	−74	7	176	<.001
Cerebellum extending to fusiform, lingual, and inferior occipital gyri	−36	−63	−13	73	.002
Placebo < CBD < control
Parahippocampal gyrus extending to midbrain and cerebellum	−18	−26	−13	82	.001
Thalamus	−7	−26	−3	33	.003
Transverse temporal gyrus extending to superior temporal gyrus	−50	−26	13	33	.004
Precentral gyrus extending to cingulate gyrus and body of caudate	−36	18	36	60	.002

Abbreviation: TAL, Talairach coordinate system.

^aCorrected for less than 1 false-positive cluster.