. 2018 Nov 6;320(17):1783–1792. doi: 10.1001/jama.2018.16501

Table 3. Stratified Analysis on the Association of the 2017 ACC/AHA Guideline Hypertension Categories on Cardiovascular Disease According to Subgroups of Antihypertensive Medication Prescription Within the First 5 Years of Follow-up.

	Systolic/Diastolic Blood Pressure Measures, mm Hg
	Normal, <120/<80 mm Hg	Elevated, 120-129/<80 mm Hg	Hypertension
	Normal, <120/<80 mm Hg	Elevated, 120-129/<80 mm Hg	Stage 1, 130-139/80-89 mm Hg	Stage 2, ≥140/≥90 mm Hg
Men
Without antihypertensive medications^a
Events	6445	2580	11 275	4486
Person-years	4 699 087	1 817 577	6 765 350	2 009 630
Incidence (events/100 000 person-years)	137	142	167	223
Adjusted HR (95% CI)^b	1 [Reference]	1.02 (0.98-1.07)	1.17 (1.13-1.21)	1.46 (1.41-1.52)
With antihypertensive medications^a
Events	1688	862	4752	4172
Person-years	257 384	119 185	673 465	567 160
Incidence (events/100 000 person-years)	656	723	706	736
Adjusted HR (95% CI)^b	1 [Reference]	1.08 (0.99-1.18)	1.03 (0.97-1.09)	1.03 (0.97-1.09)
Women
Without antihypertensive medications^a
Events	3906	672	1914	408
Person-years	4 818 403	704 185	1 806 338	246 289
Incidence (events/100 000 person-years)	81	95	106	166
Adjusted HR (95% CI)^b	1 [Reference]	1.08 (0.99-1.17)	1.18 (1.12-1.25)	1.51 (1.36-1.68)
With antihypertensive medications^a
Events	577	158	585	333
Person-years	112 833	26 986	104 168	54 721
Incidence (events/100 000 person-years)	511	585	562	609
Adjusted HR (95% CI)^b	1 [Reference]	1.10 (0.92-1.31)	1.02 (0.90-1.14)	1.04 (0.90-1.20)

Abbreviation: ACC/AHA, American College of Cardiology and American Heart Association.

^{^a}

Antihypertensive medication prescription within the first 5 years of follow-up.

^{^b}

Hazard ratio calculated by Cox proportional hazards regression analysis after adjustments for age, household income, smoking, physical activity, alcohol consumption, body mass index, fasting serum glucose, total cholesterol, and Charlson comorbidity index.