Table 1. Patient Characteristics.
| Characteristic | No. (%) | P Valuea | ||
|---|---|---|---|---|
| Patients With CIS (n = 229) | CDMS (n = 113) | Monophasic (n = 116) | ||
| Female | 167 (72.9) | 85 (75.2) | 82 (70.7) | .44 |
| Age, mean (SD), yb | 33.5 (8.2) | 32.2 (7.7) | 34.8 (8.4) | .01 |
| Follow-up time, mean (SD), mo | 65.3 (30.9) | 73.1 (29.3) | 57.6 (30.5) | <.001 |
| Clinical syndrome type | ||||
| Optic nerve | 88 (38.4) | 41 (36.3) | 47 (40.5) | .51 |
| Brainstem | 44 (19.2) | 29 (25.7) | 15 (12.9) | .01 |
| Spinal cord | 79 (34.5) | 37 (32.7) | 42 (36.2) | .94 |
| Cerebral hemispheres | 39 (17.0) | 21 (18.6) | 18 (15.5) | .54 |
| Cerebellar | 14 (6.1) | 9 (8.0) | 5 (4.3) | .25 |
| DMT at time of CIS | 55 (24.0) | 35 (31.0) | 20 (17.2) | .02 |
| OCB, >1 band, n = 148 | 111 (75.0) | 65 (83.3) | 46 (65.7) | .01 |
| Time to baseline MRI, median (IQR) | 4.0 (1.7-6.9) | 4.3 (2.0-7.5) | 3.6 (1.6-6.3) | .14 |
| MS 2010 criteria | 46 (20.1) | 33 (29.2) | 13 (11.2) | <.001 |
| MS 2017 criteria | 110 (48.0) | 73 (64.6) | 37 (31.9) | <.001 |
Abbreviations: CDMS, clinically definite multiple sclerosis; CIS, clinically isolated syndrome; DMT, disease-modifying therapies; OCB, oligoclonal bands; MS, multiple sclerosis; MRI, magnetic resonance imaging; IQR, interquartile range.
a
P value calculated between CDMS and monophasic.
b
Age at symptom onset.