Table 2. Test Characteristics for the 2010 and 2017 McDonald Criteria.
| Characteristic | DIS (n = 229) | DIT (n = 180) | DIS+DIT (n = 180) |
|---|---|---|---|
| 2010 | |||
| Sensitivity (95% CI) | 66 (56-74) | 36 (27-47) | 36 (27-47) |
| Specificity (95% CI) | 57 (47-66) | 85 (76-92) | 85 (76-92) |
| Accuracy (95% CI) | 52 (45-58) | 61 (54-68) | 61 (54-68) |
| Hazard ratio (95% CI) | 2.0 (1.3-2.9) | 1.9 (1.2-2.9) | 1.9 (1.2-2.9) |
| 2017 | |||
| Sensitivity (95% CI) | 79 (70-86) | 84 (74-90) | 68 (57-77) |
| Specificity (95% CI) | 48 (39-58) | 44 (34-55) | 61 (50-71) |
| Accuracy (95% CI) | 44 (38-51) | 64 (57-71) | 64 (57-71) |
| Hazard ratio (95% CI) | 2.7 (1.7-4.2) | 2.6 (1.5-4.6) | 2.0 (1.3-3.1) |
Abbreviations: DIS, dissemination in space; DIT, dissemination in time; NPV, negative predictive value; PPV, positive predictive value.