Table 2. Adverse Events.
| Adverse Events | No. (%) of Participants | Unadjusted Absolute Difference, % (95% CI) | |
|---|---|---|---|
| Invasive Weaning (n=182) | Noninvasive Weaning (n=182) | ||
| Antibiotics for presumed respiratory infection | 128 (70.3) | 110 (60.4) | 9.9 (0.2 to 19.6) |
| Reintubation | 41 (28.7) (n=143) | 67 (37.0) (n=181) | 8.3 (−1.9 to 18.6) |
| Tracheostomy | 55 (30.2) | 43 (23.6) | 6.6 (−2.5 to 15.7) |
| Death before intensive care unit discharge | 25 (13.7) | 22 (12.1) | 1.6 (−5.2 to 8.5) |
| Dysrhythmias | 22 (12.1) | 14 (7.7) | 4.4 (−1.7 to 10.5) |
| Nasal/skin/mouth sores or irritation | 14 (7.7) | 19 (10.4) | 2.7 (−3.2 to 8.6) |
| Nonrespiratory infection | 12 (6.6) | 11 (6.0) | 0.5 (−4.5 to 5.6) |
| Vomiting | 8 (4.4) | 14 (7.7) | 3.3 (−1.6 to 8.2) |
| Gastric distension | 6 (3.3) | 7 (3.9) | 0.5 (−3.3 to 4.4) |
| Barotrauma (eg, pneumothorax) | 3 (1.7) | 3 (1.7) | 0 (−2.6 to 2.6) |