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. 2018 Oct 15;9:2329. doi: 10.3389/fimmu.2018.02329

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Copyright © 2018 Donadelli, Pulieri, Piras, Iatropoulos, Valoti, Benigni, Remuzzi and Noris.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of the C3NeF IgG C3 convertase-stabilizing activities in the presence of properdin according to the clusters and the histology groups. Box plots show that C3 convertase-stabilizing activity against spontaneous (sPCSA) (A,C) decay did not differ among clusters or histology groups. C3 convertase-stabilizing activity against FH-mediated decay (FH-PCSA) (B,D) was significantly higher in patients of cluster 3 than in patients of clusters 1 and 2. The boxes represent the values from the 25 to 75th percentiles. The horizontal bars are the medians. Vertical lines are the 95% confidence intervals. Empty circles are values outside the 95% confidence intervals. The dashed horizontal line shows the limit of positive values (set at >mean+2SD of results with control IgGs from 26 healthy subjects). **P < 0.01.