Table 4.

Comparison of clinical, and biochemical parameters at onset and histology features between clusters.

Feature	Cluster 1 (n = 9)	Cluster 2 (n = 8)	Cluster 3 (n = 9)	P
Gender (male %)	56%	38%	67%	0.547
Age at onset (y)	13.6 (±3.55)	12.6 (±8.1)	11.6 (±5.72)	0.777
Serum C3 (mg/dl)	27 (±16.8)	22.2 (±17.2)	20.9 (±18)	0.739
Plasma sC5b9 (ng/ml)	1800 (±1150)*	1820 (±1210)*	296 (±118)	0.003
u-Protein (g/24h)	3.3 (±3.1)	5.7 (±4.9)	1.7 (±1.9)	0.099
s-Creatinine (mg/dl)	0.68 (±0.18)	0.71 (±0.19)	0.59 (±0.26)	0.426
C3 at IF	2.94 (±0.17)	2.94 (±0.18)	2.72 (±0.36)	0.137
IgG at IF	0.67 (±1.12)	2.50 (±0.54)°	0.28 (±0.44)	9.6E-06
C1q at IF	0.50 (±0.71)	1.50 (±0.89)°	0.278 (±0.44)	0.003
Mesangial deposits at EM	67%	38%	56%	0.547
Subepithelial deposits at EM	78%*	38%	11%	0.016
Subendothelial deposits at EM	100%*	100%*	0%	6.4E-07
Intramembr. highly dense deposits at EM	11%	0%	100%#	6.4E-06

EM, electron microscopy; u-protein, proteinuria; s-Creatinine, serum creatinine.

Data are expressed as mean ± SD or as % of positive patients.

^*Significantly different vs. cluster 3.

^°Significantly different vs. clusters 1 and 3.

^#Significantly different vs. clusters 1 and 2.

Bold characters indicate statistically significant values.