. 2018 Apr 18;144(11):978–987. doi: 10.1001/jamaoto.2018.0283

Table 3. Correlation Matrix Between the PROMIS Domains and Fully Demographically Adjusted NIHTB-CB Cognition Scores (Pearson Correlation Coefficient [95% CIs]).

Domain	PROMIS					NIHTB-CB
Domain	Anxiety	Depression	Self-reported Cognition	Fatigue	Pain	Fluid Cognition	Crystallized Cognition	Total Cognition
PROMIS
Anxiety	1	0.66 (0.48 to 0.79)^a	−0.45 (−0.64 to −0.21)^a	0.420 (0.18 to 0.61)^a	0.22(−0.05 to 0.45)	0.23 (−0.04 to 0.46)	0.07 (−0.2 to 0.33)	0.18 (−0.09 to 0.42)
Depression	0.66 (0.48 to 0.79)^a	1	−0.56 (−0.72 to −0.35)^a	0.565 (0.36 to 0.72)^a	0.50 (0.27 to 0.67)^a	0.045 (−0.22 to 0.31)	−0.02 (−0.29 to 0.24)	0.01 (−0.25 to 0.27)
Self-reported cognition	−0.45 (−0.64 to −0.21)^a	−0.56 (−0.72 to 0.35)^a	1	−0.45 (−0.64 to −0.21)^a	−0.48 (−0.66 to −0.25)^a	0.04 (−0.22 to 0.30)	−0.13 (−0.38 to 0.13)	−0.04 (−0.30 to 0.22)
Fatigue	0.42 (0.18 to 0.61)^a	0.56 (0.36 to 0.72)^a	−0.45 (−0.64 to −0.21)^a	1	0.59 (0.39 to 0.74)^a	−0.02 (−0.28 to 0.25)	0.05 (−0.21 to 0.31)	0.03 (−0.24 to 0.29)
Pain	0.22 (−0.05 to 0.45)	0.50 (0.27 to 0.67)^a	−0.48 (−0.66 to −0.25)^a	0.594 (0.39 to 0.74)^a	1	0.04 (−0.23 to 0.30)	0.17 (−0.10 to 0.41)	0.13 (−0.14 to 0.38)
NIHTB-CB
Fluid cognition	0.23 (−0.04 to 0.46)	0.05 (−0.22 to 0.31)	0.04 (−0.22 to 0.30)	−0.016 (−0.28 to 0.25)	0.04 (−0.23 to 0.30)	1	0.33 (0.08 to 0.55)	0.83 (0.73 to 0.90)^a
Crystallized cognition	0.07 (−0.20 to 0.33)	−0.02 (−0.29 to 0.24)	−0.13 (−0.38 to 0.13)	0.05 (−0.21 to 0.31)	0.17 (−0.10 to 0.41)	0.33 (0.08 to 0.55)^b	1	0.80 (0.68 to 0.88)^a
Total cognition	0.19 (−0.09 to 0.42)	0.01 (−0.25 to 0.27)	−0.04 (−0.30 to 0.22)	0.03 (−0.24 to 0.29)	0.13 (−0.14 to 0.38)	0.83 (0.73 to 0.90)^a	0.80 (0.68 to 0.88)^a	1

Abbreviations: NIHTB-CB, National Institutes of Health Toolbox-Cognition battery; PROMIS, Patient-Reported Outcomes Measurement System.

^{^a}

Correlation is significant at the P = .01 level (2-tailed).

^{^b}

Correlation is significant at the P = .05 level (2-tailed).