Table 2. Clinical and Demographic Characteristics by Depression Status for Patients in the Placebo Group.
| Characteristic | Patients, No. (%) | Difference, OR (95% CI) | |
|---|---|---|---|
| Never Depressed (n = 49) | Depressed (n = 16) | ||
| Age, mean (SD), y | 60.9 (12.2) | 62.8 (10.9) | −1.9 (−8.8 to 5.0) |
| QIDS-SR at baseline, mean (SD) | 4.0 (1.8) | 6.5 (2.0) | −2.5 (−3.7 to −1.3) |
| Sex | |||
| Male | 40 (82) | 13 (81) | 1.03 (0.16-4.99) |
| Female | 9 (18) | 3 (19) | |
| Urban residence | |||
| Yes | 35 (71) | 9 (56) | 0.51 (0.14-1.99) |
| No | 14 (29) | 7 (44) | |
| College education (any) | |||
| Yes | 24 (49) | 10 (62) | 1.74 (0.48-6.73) |
| No | 25 (51) | 6 (38) | |
| Clinical stage | |||
| II | 12 (24) | 3 (19) | 1.41 (0.31-8.93) |
| III or IV | 37 (76) | 13 (81) | |
| Initial treatment | |||
| Surgery (not biopsy) | 30 (61) | 4 (25) | 4.74 (1.33-16.85) |
| Radiotherapy with or without chemotherapy | 19 (39) | 12 (75) | |
| Site | |||
| Pharynx | 14 (29) | 6 (38) | 1 [Reference] |
| Oral | 24 (49) | 9 (56) | 0.88 (0.22-3.68) |
| Other | 11 (22) | 1 (6) | 0.21 (0.00-2.26) |
| Family history of depression | |||
| Yes | 6 (12) | 4 (25) | 0.42 (0.08-2.39) |
| No | 43 (88) | 12 (75) | |
| Personal history of depression | |||
| Yes | 5 (10) | 2 (12) | 0.80 (0.11-9.26) |
| No | 44 (90) | 14 (88) | |
| History of suicide attempt | |||
| Yes | 3 (6) | 0 | NA |
| No | 46 (94) | 16 (100) | |
| History of psychiatric illness | |||
| Yes | 3 (6) | 0 | NA |
| No | 46 (94) | 16 (100) | |
Abbreviations: NA, not applicable; QIDS-SR, Quick Inventory of Depressive Symptomatology–Self Report.