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. 2019 Jan 2;3:135. Originally published 2018 Oct 29. [Version 2] doi: 10.12688/wellcomeopenres.14867.2

Figure 12. A 26-gene transcriptional signature is present in blood, spleen and liver throughout the course of L. donovani infection in BALB/c mice.

Figure 12.

A. Venn diagram showing relationship between genes consistently up-regulated across time in blood, spleen and liver. B. Heat map showing expression over time for the 26 gene signature in each tissue. Data are shown as Log2FC, indicated by the scale bar. Asterisks denote that genes were also upregulated in the spleen of hamsters infected for 28 days (data from 41.) C. STRING analysis of the 26-gene signature indicates two hub genes ( Cxcl9 and Gbp1) forming a network that encompasses 21/26 (81%) of these genes.