Table 2.

Drug level and dose of immunosuppressants.

	Rejection group (n=17)	Rejection within 1 year of IS reduction (n=4)	No rejection group (n=62)	P-value*	P-value**
FK 506 TDM (ng/mL) (N/N/N)
1 month after KT (12/4/50)	9.73±3.50	9.00±3.00	9.13±3.79	0.615	0.937
First detection of BKV (17/4/62)	6.02±5.06	10.00±1.96	6.02±3.76	0.998	0.019
Peak BKV (9/4/50)	8.60±2.54	9.50±2.32	6.93±2.62	0.082	0.066
1 month after peak BKV (8/4/48)	5.46±1.06	5.68±0.62	6.43±2.40	0.073	0.562
3 months after peak BKV (9/4/48)	6.34±2.90	5.53±1.11	6.16±2.24	0.830	0.584
6 months after peak BKV (9/4/46)	5.57±2.21	5.85±1.58	5.60±1.97	0.964	0.500
1 year after peak BKV (10/4/46)	5.11±1.30	5.75±1.05	5.32±2.04	0.755	0.500
2 years after peak BKV (10/4/46)	4.21±1.92	4.75±1.15	5.48±1.63	0.034	0.478
3 years after peak BKV (10/4/44)	2.84±1.19	3.75±0.13	5.07±2.09	0.002	0.221
4 years after peak BKV (11/4/42)	3.07±1.21	3.60±1.22	4.45±1.29	0.002	0.315
5 years after peak BKV (7/1/34)	3.16±1.37	4.80	5.04±2.04	0.025	0.971
MMF (g/day)
1 month after KT (12/3/52)	1.58±0.34	1.50±0.00	1.37±0.36	0.066	0.536
First detection of BKV (12/3/55)	1.35±0.56	1.33±0.29	1.23±0.40	0.357	0.690
Peak BKV (12/3/56)	1.02±0.48	1.17±0.58	0.79±0.58	0.214	0.261
1 month after peak BKV (12/3/53)	0.69±0.47	0.67±0.76	0.40±0.52	0.082	0.509
3 months after peak BKV (12/3/55)	0.58±0.37	0.42±0.38	0.39±0.42	0.152	0.843
6 months after peak BKV (12/3/56)	0.58±0.37	0.42±0.38	0.42±0.41	0.223	0.961
1 year after peak BKV (13/4/54)	0.71±0.35	0.75±0.29	0.45±0.45	0.058	0.159
2 years after peak BKV (15/4/51)	0.78±0.36	0.88±0.25	0.56±0.37	0.043	0.111
3 years after peak BKV (14/4/53)	0.79±0.37	0.88±0.25	0.60±0.41	0.140	0.192
4 years after peak BKV (14/4/48)	0.75±0.35	0.88±0.25	0.59±0.39	0.182	0.160
5 years after peak BKV (9/2/37)	0.78±0.32	0.88±0.18	0.64±0.39	0.314	0.491

BKV – BK virus; IS – immunosuppression; KT – kidney transplantation.

^*P-value – rejection group vs. no rejection group;

^**P-value – rejection group within 1 year vs. no rejection group.