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. 2017 May 31;38(7):728–737. doi: 10.1093/carcin/bgx049

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Figure 6. — LTA4H and BLT1 influence the formation of the CDK2/cyclin E complex and the phosphorylation of CDK2 at Thr160. (A and B) A431 cells were infected with the indicated shRNAs for 48 h. Whole cell lysates were co-immunoprecipitated with anti-cyclin E followed by Western blotting with anti-CDK2 or anti-cyclin E. (C) A431 cells were infected with the indicated shRNAs for 48 h and then whole cell lysates were analyzed by Western blotting. (D) A working model of the mediation of p27 by LTA4H and/or BLT1.