Table 1.
Serum uric acid, electrolytes, and hormones in normotensive subjects
| A | B | C | B–A | C–A | C–B | |
|---|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Adjusted difference (95% CI) | Adjusted difference (95% CI) | Adjusted difference (95% CI) | |
| Serum sodium (mmol/l) | 139 (2) | 139 (2) | 139 (2) | −0.02 (−1.52, 1.47) | 1.25 (−0.46, 2.96) | 1.28 (−0.48, 3.03) |
| Serum potassium (mmol/l) | 4.2 (0.3) | 4.2 (0.3) | 4.3 (0.3) | 0.12 (−0.09, 0.34) | 0.05 (−0.20, 0.30) | −0.07 (−0.33, 0.18) |
| Serum urea (mmol/l) | 5.2 (1.3) | 5.6 (1.6) | 5.1 (1.1) | 0.61 (−0.15, 1.38) | −0.03 (−0.90, 0.84) | −0.64 (−1.54, 0.25) |
| Serum creatinine (mmol/l) | 79 (9) | 80 (8) | 79 (9) | −0.87 (−5.55, 3.81) | −2.93 (−8.26, 2.40) | −2.06 (−7.57, 3.45) |
| Serum uric acid (mmol/l) | 0.29 (0.07) | 0.28 (0.07) | 0.27 (0.07) | −0.01 (−0.03, 0.02) | −0.04 (−0.06, −0.01)** | −0.03 (0.08, 0.00) |
| Serum renin activity (nmol.l−1.s−1) | 1.6 (0.7) | 1.1 (0.5) | 1.1 (0.4) | −0.47 (−0.81, −0.14)** | −0.60 (−1.01, −0.18)** | −0.12 (−0.56, 0.31) |
| Serum aldosterone (pmol/l) | 549 (342) | 293 (182) | 297 (161) | −259 (−394, −124)*** | −205 (−384, −27)* | 54 (−132, 239) |
A = 60 mmol sodium/day, B = 150 mmol/day, C = 200–250 mmol/day. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. Serum uric acid, electrolytes, and hormones are reported for week 4 (end of intervention) and as adjusted differences between interventions A, B, and C. Analysis adjusted for week 0, order, and time. Abbreviation: CI, confidence interval.