Figure 1.

Artificial lesioning procedure for one subject. The weights of nodes from the original mean healthy SC matrix (A) are reduced or lesioned based on the lesion severity of one sample subject (B). Once this subject-specific lesioned SC is generated, whole-brain modeling is performed and a modeled stroke FC is fitted to its corresponding empirical stroke FC (C). Then, node entropy is calculated in lesioned nodes (yellow node in toy network) both from the empirical and modeled FC to finally explore the relation of entropy and lesion severity (distribution represented as a histogram) across all subjects (D).