Table 3.
The association of D4Z4 methylation with BCR
| D4Z4 methylation | No BCR | BCR | Adjusted HRa (95% CI) | P value |
|---|---|---|---|---|
| N (%) | N (%) | |||
| Overall | ||||
| First and second tertile | 488 (88.25) | 65 (11.75) | Reference | N/A |
| Third tertile (highest) | 195 (84.42) | 36 (15.58) | 1.74 (1.14–2.65) | 0.0096 |
| Site 1 | ||||
| First and second tertile | 494 (87.43) | 71 (12.57) | Reference | N/A |
| Third tertile (highest) | 189 (86.30) | 30 (13.70) | 1.38 (0.89–2.15) | 0.144 |
| Site 2 | ||||
| First and second tertile | 478 (88.68) | 61 (11.32) | Reference | N/A |
| Third tertile (highest) | 205 (83.67) | 40 (16.33) | 1.80 (1.19–2.72) | 0.0055 |
| Site 3 | ||||
| First and second tertile | 471 (86.90) | 71 (13.10) | Reference | N/A |
| Third tertile (highest) | 212 (87.60) | 30 (12.40) | 1.30 (0.84–2.01) | 0.246 |
| Site 4 | ||||
| First and second tertile | 489 (87.32) | 71 (12.68) | Reference | N/A |
| Third tertile (highest) | 194 (86.61) | 30 (13.39) | 1.24 (0.80–1.92) | 0.326 |
aAdjusted for age, body mass index, smoking status, pack-year, D’Amico risk groups and primary treatment.