Table 4.
D4Z4 methylation | No BCR | BCR | Adjusted HRa (95% CI) | P value |
---|---|---|---|---|
N (%) | N (%) | |||
Overall | ||||
First and second tertile | 344 (86.00) | 50 (13.85) | Reference | |
Third tertile (highest) | 116 (80.00) | 29 (20.00) | 2.17 (1.36–3.48) | 0.001 |
Site 1 | ||||
First and second tertile | 318 (85.03) | 56 (14.97) | Reference | N/A |
Third tertile (highest) | 109 (82.58) | 23 (17.42) | 1.67 (1.01–2.75) | 0.044 |
Site 2 | ||||
First and second tertile | 305 (86.65) | 47 (13.35) | Reference | N/A |
Third tertile (highest) | 122 (79.22) | 32 (20.78) | 2.21 (1.38–3.52) | 0.0009 |
Site 3 | ||||
First and second tertile | 294 (84.24) | 55 (15.76) | Reference | N/A |
Third tertile (highest) | 133 (84.71) | 24 (15.29) | 1.44 (0.88–2.37) | 0.150 |
Site 4 | ||||
First and second tertile | 304 (84.92) | 54 (15.08) | Reference | N/A |
Third tertile (highest) | 123 (83.11) | 25 (16.89) | 1.50 (.92–2.42) | 0.103 |
aAdjusted for age, body mass index, smoking status, pack-year, D’Amico risk groups and primary treatment.
Bold values indicate P < 0.05.