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. 2017 Jul 6;38(8):821–826. doi: 10.1093/carcin/bgx064

Table 4.

The association of D4Z4 methylation with BCR among localized PCa patients who received active treatments

D4Z4 methylation No BCR BCR Adjusted HRa (95% CI) P value
N (%) N (%)
Overall
 First and second tertile 344 (86.00) 50 (13.85) Reference
 Third tertile (highest) 116 (80.00) 29 (20.00) 2.17 (1.363.48) 0.001
Site 1
 First and second tertile 318 (85.03) 56 (14.97) Reference N/A
 Third tertile (highest) 109 (82.58) 23 (17.42) 1.67 (1.012.75) 0.044
Site 2
 First and second tertile 305 (86.65) 47 (13.35) Reference N/A
 Third tertile (highest) 122 (79.22) 32 (20.78) 2.21 (1.383.52) 0.0009
Site 3
 First and second tertile 294 (84.24) 55 (15.76) Reference N/A
 Third tertile (highest) 133 (84.71) 24 (15.29) 1.44 (0.88–2.37) 0.150
Site 4
 First and second tertile 304 (84.92) 54 (15.08) Reference N/A
 Third tertile (highest) 123 (83.11) 25 (16.89) 1.50 (.92–2.42) 0.103

aAdjusted for age, body mass index, smoking status, pack-year, D’Amico risk groups and primary treatment.

Bold values indicate P < 0.05.