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. 2017 Nov 16;98(3):396–407. doi: 10.1093/biolre/iox147

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© The Author(s) 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Figure 1. — Significantly enriched biological concepts among differentially expressed genes in GBS-treated extraplacental membrane cultures. Extraplacental membranes were obtained from pregnant donors and inoculated with GBS for 4, 8, or 24 h followed by RNA extraction. Microarray analysis was used to identify differentially expressed genes. LRPath software was then used to identify significantly enriched biological concepts (e.g., KEGG pathways, GO terms) among differentially expressed genes. Enriched biological concepts were identified by an enrichment P-value < 0.001 for at least two time points. Color intensity indicates log2(odds ratio) for enrichment (green = downregulated concepts, red = upregulated concepts).