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. 2017 Mar 14;140(5):1420–1436. doi: 10.1093/brain/awx044

Figure 2.

Figure 2

Oligodendrocytes are insulin resistant in MSA. Representative images of IRS-1pS312 and IRS-1pS616 staining in oligodendrocytes of controls (n = 5) (A and E) and MSA patients (n = 7) (B and F). The number of IRS-1pS312 and IRS-1pS616 positive oligodendrocytes was similar in both groups (C and G). IRS-1pS312 staining intensity is increased in oligodendrocytes of MSA patients (n = 7) compared to healthy controls (n = 5) (D). Quantification of IRS-1pS616 staining intensity showed no significant difference between groups (H). Scale bar = 10 µm. A t-test was used to compare data between MSA patients and healthy controls. If data were not normally distributed, a Mann-Whitney test was used instead. Values are mean ± SEM. *P < 0.05 versus controls. A.U. = arbitrary units.