Table 2.

Unadjusted and Adjusted Comparison of 52 Postpartum Women Tested for the Interleukin-28B Gene Allele Who Spontaneously Cleared Their Chronic Hepatitis C Virus Infection and Those Who Remained Persistently Infected^a

Characteristic	Model 1		Model 2		Model 3
	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value
Age			1.00 (.97, 1.03)	.97	1.01 (.97, 1.04)	.62
Log maternal hepatitis C viral load at baseline			1.01 (.94, 1.07)	.67	1.01 (.93, 1.07)	.73
Interleukin-28B gene (rs12979860)
CC allele (n = 28)	Reference	–	Reference	–	Reference	–
CT allele (n = 17)	0.79 (.62, 1.01)	.07	0.78 (.60, 1.01)	.08	0.75 (.57, 1.00)	.05
TT allele (n = 7)	0.93 (.64, 1.41)	.66	0.93 (.62, 1.42)	.69	0.91 (.61, 1.38)	.64
Number of full-term births (n = 47)			0.96 (.87, 1.07)	.50	0.94 (.84, 1.05)	.30
History of abortion (n = 17)					1.05 (.87, 1.26)	.54
History of surgery (n = 34)					1.23 (.91, 1.68)	.15
History of blood transfusion (n = 4)					0.95 (.51, 1.80)	.83
History of dental treatment (n = 42)					1.21 (.87, 1.65)	.29

Model 1 is unadjusted; model 2 adjusts for age, log baseline viral load, and number of full-term births; and model 3 adjusts for the same variables in model 2 as well as risk factors for infection. Cells with data too sparse to be calculated were excluded from the adjusted model (history of preterm births, working in the health sector, history of jaundice, history of liver disease, history of needle-stick injury, history of tattoos, history of endoscopy, history of renal dialysis, and history of intravenous injection with needle sharing). The variable “having children who are currently alive” strongly correlated with “number of full-term births” and was also excluded from the model. ORs were estimated using logistic regression. P values derived using permutation tests based on 5000 permutations. CIs were derived using 5000 bootstrap replicates.

Abbreviations: CI, confidence interval; OR, odds ratio.

a14 women spontaneously cleared their chronic HCV infection and 38 remained persistently infected.