Table 1.
Clinical evidence of RAS/GEF GTP pathway associated with glioblastoma (GB)
| Gene | Cancer type | Fold change (GB/Normal) |
P-value | Gene rank | Data set (number of patients) | Ref |
|---|---|---|---|---|---|---|
| CTNNAL1 | Glioblastoma versus normal | 2.177 | 1.51E−11 | 79 | TCGA Brain (557) | TCGA |
| Glioblastoma versus normal | 2.984 | 1.42E−16 | 266 | Sun Brain (180) | (17) | |
| Glioblastoma versus normal | 1.432 | 9.08E−04 | 1648 | Bredel Brain 2 (54) | (16) | |
| ASAP1 | Glioblastoma versus normal | 1.181 | 0.003 | 1321 | Freije Brain (85) | (30) |
| Glioblastoma versus normal | 1.777 | 0.036 | 293 | Liang Brain (38) | (15) | |
| Secondary glioblastoma versus normal | 1.157 | 0.002 | 1186 | DNA Beroukhim Brain (187) | (31) | |
| Glioblastoma versus normal | 1.034 | 1.79E−10 | 1605 | DNA TCGA Brain 2 (1,531) | TCGA | |
| Glioblastoma versus normal | 1.478 | 3.45E−06 | 2068 | Sun Brain (180) | (17) | |
| Glioblastoma versus normal | 4.916 | 5.15E−26 | 10 | TCGA Brain (557) | TCGA | |
| CD44 | Glioblastoma versus normal | 7.243 | 1.17E−15 | 21 | Bredel Brain 2 (54) | (16) |
| Glioblastoma versus normal | 4.142 | 3.36E−09 | 35 | Liang Brain (38) | (15) | |
| Glioblastoma versus normal | 6.456 | 3.30E−23 | 77 | Sun Brain (180) | (17) | |
| Glioblastoma versus normal | 3.592 | 3.46E−08 | 81 | Shai Brain (42) | (32) | |
| Glioblastoma versus normal | 2.591 | 7.09E−18 | 86 | Murat Brain (84) | (33) | |
| Glioblastoma versus normal | 3.14 | 1.47E−04 | 907 | Lee Brain (101) | (34) |