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Primary cutaneous extranodal marginal zone lymphoma. Case SH2015-116 (Dr Gong, National Cancer Institute) of a 70-year-old male patient with multiple skin lesions exemplifies a primary cutaneous extranodal marginal zone lymphoma in the immunodeficiency setting (immune senescence related) with a spectrum of small lymphocytes to plasma cell differentiation (A-C, CD79a; A, x4; B and C, x10). EBV-encoded small RNA (EBER) is positive in up to 50% of neoplastic cells (D, EBER, x10).
