Table 5.

Group differences in resting-state functional connectivity of selected seed regions between trans men and controls before start of testosterone treatment

Region	Session 1: Controls > Trans men						Session 1: Trans men > Controls
	Peak level Z	k	x	y	z	PFWE	Peak level Z	k	x	y	z	PFWE
pACC seed
L pACC
R insular cortex	6.0	170	30	18	−12	<0.001		n.s.
R nc. caudatus	5.9	181	16	18	3	<0.001
L precuneus	5.6	554	−3	−54	16	<0.001
L nc. caudatus	5.5	80	−14	18	1	<0.001
R ant. midtemporal gyrus	5.3	79	57	0	−21	<0.001
L ant. paracingulate gyrus	5.2	53	−2	23	36	0.001
R ant. hypothalamus	5.0	51	2	10	−6	0.001
R pACC
R nc. caudatus	5.5	91	16	20	–6	<0.001		n.s.
L ant. cingulate gyrus	5.4	66	−9	24	28	<0.001
R orbito-frontal cortex	5.2	119	40	22	−12	<0.001
TPJ seed
L TPJ
L medial frontal gyrus	6.0	164	−2	58	18	<0.001		n.s.
L precuneus	6.0	692	−4	–60	31	<0.001
R TPJ	5.9	497	63	−54	22	<0.001
R ant. midtemporal gyrus	5.9	87	60	–6	−26	<0.001
L post. midtemporal gyrus	5.7	63	−57	−33	−14	<0.001
L frontal pole	5.6	169	−18	42	40	<0.001
L superior frontal gyrus	5.5	89	−3	33	46	<0.001
L post. midfrontal gyrus	5.5	56	−57	−19	−17	0.001
L frontal pole	5.3	55	−15	66	13	0.001
R TPJ
L TPJ	7.4	2871	−45	–75	27	<0.001
L precuneus	5.9	1070	−2	–63	24	<0.001
R paracingulate gyrus	5.7	101	8	50	12	<0.001
R medial frontal gyrus	5.4	116	4	50	39	<0.001
R superior frontal gyrus	5.3	53	21	29	46	0.001
L insular cortex							4.3	133	−33	8	15	0.093
R insular cortex							3.8	72	33	12	13	0.207

x y z = coordinates in MNI space; k = number of voxels; R, right, L, left; results are reported at a cluster-level threshold of P < 0.05, family-wise error (FWE) corrected and a minimal cluster size of 50 voxels result in italic are based on a threshold of P< 0.001, uncorrected and a minimal cluster size of 50 voxels; auto-correlations with the seed region are not listed as results.