Table 6.

Testosterone treatment effects on resting-state functional connectivity of selected seed regions in trans men

Region	Session 1 > session 2 (decreased connectivity with treatment)						Session 2 > session 1 (increased connectivity with treatment)
	Peak level Z	k	x	y	z	PFWE	Peak level Z	k	x	y	z	PFWE
pACC seed
L pACC
L insular cortex							4.3	288	−32	20	−9	0.043
R pACC
L angular gyrus	4.1	290	−44	–60	16	0.043
R paracingulate gyrus							4.1	294	12	33	24	0.040
TPJ seed
L TPJ
L paracingulate gyrus							6.3	7499	−6	44	36	<0.001
L inf. frontal gyrus							5.5	868	−48	23	1	<0.001
R TPJ							5.4	1871	52	−55	25	<0.001
L precuneus							4.8	1176	−14	–49	27	<0.001
L midtemporal gyrus							4.5	696	−52	−25	−14	<0.001
R midtemporal gyrus							4.5	627	63	−28	−11	<0.001
L midfrontal gyrus							4.4	694	−38	21	43	<0.001
R midfrontal gyrus							4.4	448	46	20	40	0.004
R TPJ
L insular cortex	4.0	364	−40	2	3	0.016
L inf. frontal gyrus	4.7	977	−33	30	4	<0.001
L precuneus							4.6	2035	−3	−55	22	<0.001
L TPJ							4.4	980	−52	−66	31	<0.001

x y z = coordinates in MNI space; k = number of voxels; R = right, L = left; results are reported at a cluster-level threshold of P < 0.05, family-wise error (FWE) corrected and a minimal cluster size of 50 voxels; auto-correlations with the seed region are not listed as results.